(CNN) Greater than 1,400 flights have been canceled in the USA on Wednesday as a winter storm hit the nation.

As of two:30 p.m. ET Wednesday, a complete of 1,442 flights out and in of the US had been canceled, in response to flight monitoring website FlightAware. Regional provider SkyWest, which operates by way of partnerships with United, Delta, American and Alaska Airways, had canceled about 350 flights. Delta and Southwest had each canceled about 250 flights.

Minneapolis−Saint Paul Worldwide Airport, Denver Worldwide Airport and Detroit Metropolitan Wayne County Airport have been probably the most closely affected, in response to FlightAware. Chicago O’Hare Worldwide Airport, Toronto Pearson Worldwide Airport and Milwaukee Mitchell Worldwide Airport have been additionally experiencing disruption.

Southwest Airways has issued winter climate waivers for a couple of dozen airports.

Delta Air Strains has issued waivers for Higher Midwest winter climate and Rockies and Mountain areas winter climate.

American Airways and United have additionally issued winter climate waivers for journey this week.

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The flight disruption comes after winter climate alerts have been issued throughout 29 states, together with California, Minnesota and Maine, with warnings of extreme icing, excessive chilly and sleet as a part of the three-day storm.

The Minneapolis space of Minnesota is susceptible to selecting up at the least 15 inches of snow, with the Nationwide Climate Service in Minnesota’s Twin Cities warning the highly effective storm “will convey widespread accumulating snow, with blowing and drifting snow primarily Wednesday by way of Thursday.”

Correction: A earlier model of this story misidentified Delta Air Strains.

CNN’s Aya Elamroussi additionally contributed to this text